IgG glycation and function during continuous ambulatory peritoneal dialysis.

  title={IgG glycation and function during continuous ambulatory peritoneal dialysis.},
  author={J C Davin and Antonia H. M. Bouts and Raymond Theodorus Krediet and M B van der Weel and Ron S. Weening and J Groothoff and Theo A. Out},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={12 2},
IgG in dialysate may have an important role in anti-infection mechanisms during continuous ambulatory peritoneal dialysis (CAPD). As Fc fragment oligosaccharidic chains are crucial for IgG effector functions, we have tested the hypothesis that IgG glycation might occur during CAPD and modify IgG properties. Purified normal IgG was incubated with glucose solutions of different concentrations and pH. Separation of glycated IgG was performed by affinity chromatography. Complement activation (C3c… CONTINUE READING


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