IgG from patients with Guillain-Barré syndrome interact with nicotinic acetylcholine receptor channels.

@article{Krampfl2003IgGFP,
  title={IgG from patients with Guillain-Barr{\'e} syndrome interact with nicotinic acetylcholine receptor channels.},
  author={Klaus Krampfl and Bahram Mohammadi and Brigitte Buchwald and Klaus Jahn and R. Dengler and Klaus Viktor Toyka and Johannes Bufler},
  journal={Muscle & nerve},
  year={2003},
  volume={27 4},
  pages={435-41}
}
In Guillain-Barré syndrome (GBS), immunoglobulin G (IgG) antibodies block neuromuscular transmission pre- and postsynaptically and thus are of potential pathogenic relevance. We investigated whether IgG from GBS patients has a direct interaction with nicotinic acetylcholine receptor (nAChR) channels. Purified IgG fractions from six GBS patients that blocked neuromuscular transmission in a previous study were analyzed by the patch-clamp technique in combination with an ultrafast system for… CONTINUE READING

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