IgG deposits can be detected in cell nuclei of patients with both lupus erythematosus and malignancy

@article{Bhm2007IgGDC,
  title={IgG deposits can be detected in cell nuclei of patients with both lupus erythematosus and malignancy},
  author={I. B{\"o}hm},
  journal={Clinical Rheumatology},
  year={2007},
  volume={26},
  pages={1877-1882}
}
  • I. Böhm
  • Published 2007
  • Medicine
  • Clinical Rheumatology
The purpose was to find immunological disturbances in lupus erythematosus (LE) patients with concomitant malignancy. 159 LE patients have been analyzed. Routine laboratory analyses including screening of serum autoantibodies and analyzing peripheral blood mononuclear cells by using flow cytometry have been performed. Malignant diseases have been revealed in 12 (7.5%) cases. All patients suffered from internal malignancies. LE patients with vs without malignancy had significantly decreased anti… Expand
4 Citations
Breast cancer in lupus.
TLDR
The presented data suggest that BC is the most common malignancy in patients with ILE, and SLE is no prerequisite to acquire an oncological disease. Expand
DNA-hydrolyzing Ab: Is catalytic activity a clue for physiological significance?
TLDR
Apo processes, e.g., induced by DNA-hydrolyzing Ab, may underlie a number of syndromes observed in autoimmunity thus providing the grounds for the pathological role of DNA- dehydration Ab in these diseases. Expand
Laparoscopic versus Lichtenstein hernioplasty for inguinal hernias: a systematic review and Meta-analysis of randomized controlled trials
  • Li Sun, Yingmo Shen, J. Chen
  • Medicine
  • Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy
  • 2019
TLDR
It was demonstrated that laparoscopic repair reduced chronic pain and wound infection compared with Lichtenstein repair, but Lichtentein could reduce the operative time and hernia recurrence. Expand

References

SHOWING 1-10 OF 36 REFERENCES
Apoptosis: the link between autoantibodies and leuko-/lymphocytopenia in patients with lupus erythematosus
  • I. Böhm
  • Medicine
  • Scandinavian journal of rheumatology
  • 2004
TLDR
The data suggest that autoantibodies may be associated with blood cytopenias, and CD95 seems to play a central role in this signalling cascade. Expand
Antineural and antinuclear autoantibodies are of prognostic relevance in non-small cell lung cancer.
TLDR
Cox regression analysis showed that antineural and antinuclear antibodies are a stage-independent prognostic factor in patients with NSCLC and may represent an effective immune response to the tumor. Expand
Concomitant manifestation of systemic lupus erythematosus and low-grade non-Hodgkin’s lymphoma
TLDR
The observations made in this patient led us to discuss the role of the CD5+ population in the development of rheumatic disorders and concomitant lymphoid malignancy. Expand
Malignancy in Systemic Lupus Erythematosus: a Report of Five Cases in a Series of 96 Patients
TLDR
Patients with SLE may have the same malignancies as the general population after adjustment for age and sex, but there are no predictive indicators for malignancy and immunosuppressive therapy may be a contributing factor. Expand
The prognostic significance of autoantibodies against dsDNA in patients with colorectal adenocarcinoma.
TLDR
The presence of anti-dsDNA autoantibodies in patients with colorectal cancer indicated a better outcome of the course of the disease. Expand
Malignancy in systemic lupus erythematosus.
TLDR
SLE is associated with a lower risk of all cancers compared with RA and SSc, but an increased risk for non-Hodgkin's lymphoma compared with the general population. Expand
Antibody penetration into living cells. I. Intranuclear immunoglobulin in peripheral blood mononuclear cells in mixed connective tissue disease and systemic lupus erythematosus.
TLDR
In vivo penetration of autoantibodies into Fc receptor-bearing cells in MCTD, and probably in SLE as well, may represent an important pathogenetic mechanism. Expand
Systemic lupus erythematosus and Hodgkin's lymphoma.
TLDR
Persistent lymphadenopathic features, especially mediastinal and/or retroperitoneal lymphadenopathy, eosinophilia and generalized pruritus in a patient with SLE not responding to treatment may be indicative of coexistent Hodgkin's lymphoma. Expand
Penetrating anti-DNA monoclonal antibodies induce activation of human peripheral blood mononuclear cells.
TLDR
Data indicate that penetrating anti-DNA Ab are able to induce an anomalous activation state in vitro in a significant fraction of PBMNC, and it is believed this effect may occur in vivo and could have an important function in the pathogenesis of the immune dysregulation seen in SLE. Expand
Anti-DNA autoantibodies reveal toxicity to tumor cell lines.
TLDR
It was shown that treatment of the cells with cytotoxic anti-DNA autoantibodies induced internucleosomal DNA fragmentation and Annexin V binding to the cell surface characteristic of apoptotic pathway of cell death. Expand
...
1
2
3
4
...