IgG cooperativity – Is there allostery? Implications for antibody functions and therapeutic antibody development

@inproceedings{Yang2017IgGC,
  title={IgG cooperativity – Is there allostery? Implications for antibody functions and therapeutic antibody development},
  author={Danlin Yang and Rachel Kroe-Barrett and Sanjaya Singh and Christopher J Roberts and Thomas M. Laue},
  booktitle={mAbs},
  year={2017}
}
A central dogma in immunology is that an antibody's in vivo functionality is mediated by 2 independent events: antigen binding by the variable (V) region, followed by effector activation by the constant (C) region. However, this view has recently been challenged by reports suggesting allostery exists between the 2 regions, triggered by conformational changes or configurational differences. The possibility of allosteric signals propagating through the IgG domains complicates our understanding of… CONTINUE READING
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