IgG against extracellular subdomains of desmoglein 3 relates to clinical phenotype of pemphigus vulgaris.

@article{Mller2008IgGAE,
  title={IgG against extracellular subdomains of desmoglein 3 relates to clinical phenotype of pemphigus vulgaris.},
  author={Ralf M{\"u}ller and Vera Svoboda and Elke Wenzel and H. M{\"u}ller and Michael Hertl},
  journal={Experimental dermatology},
  year={2008},
  volume={17 1},
  pages={
          35-43
        }
}
Pemphigus vulgaris (PV) is associated with autoantibodies against desmoglein (Dsg) 3 inducing epidermal loss of adhesion. The major pathogenic epitopes of Dsg3 are presumably dependent of their conformation. The aim of this study was to characterize the IgG reactivity of sera from a cohort of clinically well-characterized PV patients against presumably non-conformational subdomains of the Dsg3 ectodomain including recently described NH2-terminal immunodominant epitopes. By ELISA, IgG reactivity… CONTINUE READING
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