IgG Subclasses and Allotypes: From Structure to Effector Functions

  title={IgG Subclasses and Allotypes: From Structure to Effector Functions},
  author={Gestur Vidarsson and Gillian Dekkers and Theo Rispens},
  booktitle={Front. Immunol.},
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These regions are involved in binding to both IgG-Fc receptors (FcγR) and C1q. As a result, the different subclasses have different effector functions, both in terms of triggering FcγR-expressing cells, resulting in phagocytosis or antibody… CONTINUE READING
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