IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis

Abstract

BACKGROUND Methotrexate (MTX) is the standard first-line therapy in rheumatoid arthritis (RA) with variable clinical efficacy that is difficult to predict. The glycosylation status of immunoglobulin G (IgG) is altered in RA and influenced by MTX treatment. We aimed to further investigate if IgG glycosylation in untreated early RA can predict therapeutic… (More)
DOI: 10.1186/s13075-017-1389-7

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