IgE to α-Gal in Foresters and Forest Workers From La Rioja, North of Spain.

@article{Venturini2017IgET,
  title={IgE to $\alpha$-Gal in Foresters and Forest Workers From La Rioja, North of Spain.},
  author={M{\'o}nica Venturini and Te{\'o}filo Lobera and A B Sebastian and Ar{\'a}nzazu Portillo and Jes{\'u}s Oteo},
  journal={Journal of investigational allergology \& clinical immunology},
  year={2017},
  volume={28 2},
  pages={
          106-112
        }
}
OBJECTIVE To investigate the prevalence of and factors associated with the presence of α-gal-specific IgE in a risk group of foresters and forest workers from La Rioja, Spain and in a control group. METHODS The study population comprised 169 workers and 100 individuals who did not recall having had tick bites. A questionnaire including demographic data and number of tick bites per year was completed by a physician. α-Gal sIgE was assessed using ImmunoCAP with serum samples that had been taken… 

Tables from this paper

Sensitisation and allergic reactions to alpha-1,3-galactose in Podlasie, Poland, an area endemic for tick-borne infections

The data support the link between I.ricinus ticks and the production of α-gal sIgE and confirm that the pathogens carried by ticks the authors examined for do not seem implicated in this immune response.

IgE-mediated sensitization to galactose-alpha-1,3-galactose (α-gal) in urticaria and anaphylaxis in Spain: geographical variations and risk factors.

A positive result of sIgE to α-gal associated with history of tick bites, participation in outdoor activities, pet ownership, and ingestion of mammalian meats or innards before the onset of symptoms could be implicated as a cofactor.

Cross‐reactivity between tick and wasp venom can contribute to frequent wasp sensitization in patients with the α‐Gal syndrome

For the first time, cross‐reactivity between wasp venom and tick proteins has been described and may be a reason why the majority of Swedish AGS patients, who have all been tick bitten, are also sensitized against wasp.

Alpha-gal syndrome: challenges to understanding sensitization and clinical reactions to alpha-gal

The current α- Gal syndrome diagnosis based on anti-α-Gal IgE titers is discussed and an algorithm that considers all co-factors in the clinical history of α-Gal-sensitized patients to be incorporated into the AGS diagnosis is proposed.

Galactose α-1,3-galactose phenotypes: Lessons from various patient populations.

Alpha‐gal syndrome: An emerging cause of food and drug allergy

This review summarises recent advances in the understanding of α‐gal syndrome, its clinical presentation, pathomechanism and role of various tick species in the development of AGS.

The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose.

Impaired allergy diagnostics among parasite-infected patients caused by IgE antibodies to the carbohydrate epitope galactose-α 1,3-galactose.

Red meat allergy in Sweden: association with tick sensitization and B-negative blood groups.

Prevalence of type I sensitization to alpha‐gal in forest service employees and hunters

The production of IgE molecules specific to the carbohydrate galactose‐α‐1,3‐galactose (alpha‐gal) is known to induce delayed anaphylaxis against mammalian meat and the reported prevalence of alpha‐gal‐specific IgE (alpha-gal‐sIgE) positivity varies between different populations from diverse geographic regions.

Delayed Anaphylaxis to Red Meat Associated With Specific IgE Antibodies to Galactose

It is hypothesize that hard tick saliva is enriched with blood-type substances, such as oligosaccharides, from the non-primate mammal victim's blood after days to weeks of blood sucking, which sensitizes humans through the injection route while blood sucking.

Galactose-α-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma.

These results provide a model of an ectoparasite-induced specific IgE response that can increase total serum IgE without creating a risk for asthma, and further evidence that the main allergens that are causally related to asthma are those that are inhaled.

Skin prick test and basophil reactivity to cetuximab in patients with IgE to alpha‐gal and allergy to red meat

Skin prick tests and basophil activation test using cetuximab may be a more sensitive alternative in patients with an assumed allergy to meat.

Identification of galactose‐α‐1,3‐galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy

The first direct evidence that α‐Gal is present within ticks is provided thus potentially explaining the relationship between tick exposure and sensitization to α‐ Gal, with development of red meat allergy as a secondary phenomena.

Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose.

IgE antibodies to galactose-α-1,3galactose in pretreatment serum samples from 17 of 25 patients who had hypersensitivity reactions to cetuximab, whereas IgE antibodies were found in only 1 of 51 patients who did not have a hypersensitivity reaction.

Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galactose.