IgE production in rat fascioliasis

@article{Pfister1983IgEPI,
  title={IgE production in rat fascioliasis},
  author={Kurt Pfister and K Turner and Allan Currie and Eliza Hall and Ellen E. E. Jarrett},
  journal={Parasite Immunology},
  year={1983},
  volume={5}
}
Summary F. hepatica infection of rats caused a prolonged elevation of serum total IgE reflecting the continued presence of live worms in the host. Infection with 40 metacercariae stimulated higher total IgE levels than infection with 20 metacer‐cariae. The parasite specific IgE response was biphasic, the first peak coinciding with the migratory phase in the liver parenchyma and the second with the establishment of flukes in the bile ducts. 
Role of IgE in fascioliasis
TLDR
It has been found that F. hepatica infections in rats — similarly to other helminth infections — were able to potentiate an unrelated IgE response, and the significance of these reactions is not yet understood and further investigations might possibly show wether circulating IgE can perform some regulatory mechanisms in immunity to liver fluke infections. Expand
Worm recovery, haemagglutinating antibodies and IgE-levels after immunisation against Fasciola hepatica in rats.
TLDR
The present results suggest that both the adjuvant and the route of administration are crucial for the stimulation of a protective immunity to F. hepatica, and support the hypothesis of an immunomodulatory effect caused by the vaccination scheme. Expand
Humoral and cellular immune responses to Fasciola hepatica experimental primary and secondary infection in sheep.
TLDR
Blood leukocyte changes, serum hepatic enzyme levels, lymphocyte proliferation in response to Concanavalin A and to parasitic excretory-secretory products (FhESP), and antibody responses (ELISA and Western blot) were studied in sheep during the first 3 months of an experimental primary or secondary infection. Expand
[Serum IgE levels in rats infected with Paragonimus westermani].
  • M. Shin, J. Ryu, D. Min
  • Biology, Medicine
  • Kisaengch'unghak chapchi. The Korean journal of parasitology
  • 1991
TLDR
The present results suggested that P. westermani could elevate serum IgE and specific IgG antibodies in Wistar rats which were not a good definitive host. Expand
Immunological approaches for the control of fasciolosis.
TLDR
Analysis of immune responses to Fasciola during infection in ruminants suggests that chronic infection correlates with a type 2 helper T cell response, implying that type 1 helpers T cell responses are down-regulated in fasciolosis. Expand
Immunization with cathepsin L proteinases CL1 and CL2 secreted by Fasciola hepatica elicit a preferential type 1 response based on IgG2a antibodies in rats.
Cathepsin L proteinases (CL1 and CL2), the major components of Fasciola hepatica excretion/secretion products (E/S) are considered potential antigens of a vaccine against fascioliasis. The humoralExpand
Cellular reactions in the small intestine of rats after infection withFasciola hepatica
TLDR
The pattern of these defence reactions in the small intestine suggests some similarities with the mechanisms of antibody-dependent cell-mediated cytotoxicity that have been shown to take place during Schistosoma mansoni reinfection. Expand
Local immune response to experimental Fasciola hepatica infection in sheep.
TLDR
The migratory tunnels produced by juvenile flukes appeared as local areas of necrosis surrounded by infiltrating inflammatory cells, particularly numerous macrophages, eosinophils and OvCD4+ lymphocytes n addition, B lymphocyte proliferation was observed in hepatic lymph nodes and in liver portal tracts. Expand
Worm kinetics and serum IgE in hooded lister rats infected with the acanthocephalan Moniliformis moniliformis and the nematode Nippostrongylus brasiliensis.
TLDR
Anthelminthic removal of M. moniliformis revealed that the presence of residual worms was necessary to maintain worm-specific IgE production, and a peak response was observed about 1 month after the sera turned positive. Expand
IgE responses in human gnathostomiasis.
TLDR
There was almost a 10-fold rise in the total IgE in the serum of patients with proven gnathostomiasis and in those with intermittent cutaneous migratory swellings, indicating that G. spinigerum infection potentiates IgE production similarly to many other nematode parasites. Expand
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