IgE production in rat fascioliasis

  title={IgE production in rat fascioliasis},
  author={Kurt Pfister and K Turner and Allan Currie and Eliza Hall and Ellen E. E. Jarrett},
  journal={Parasite Immunology},
Summary F. hepatica infection of rats caused a prolonged elevation of serum total IgE reflecting the continued presence of live worms in the host. Infection with 40 metacercariae stimulated higher total IgE levels than infection with 20 metacer‐cariae. The parasite specific IgE response was biphasic, the first peak coinciding with the migratory phase in the liver parenchyma and the second with the establishment of flukes in the bile ducts. 
Role of IgE in fascioliasis
It has been found that F. hepatica infections in rats — similarly to other helminth infections — were able to potentiate an unrelated IgE response, and the significance of these reactions is not yet understood and further investigations might possibly show wether circulating IgE can perform some regulatory mechanisms in immunity to liver fluke infections. Expand
Worm recovery, haemagglutinating antibodies and IgE-levels after immunisation against Fasciola hepatica in rats.
The present results suggest that both the adjuvant and the route of administration are crucial for the stimulation of a protective immunity to F. hepatica, and support the hypothesis of an immunomodulatory effect caused by the vaccination scheme. Expand
Humoral and cellular immune responses to Fasciola hepatica experimental primary and secondary infection in sheep.
Blood leukocyte changes, serum hepatic enzyme levels, lymphocyte proliferation in response to Concanavalin A and to parasitic excretory-secretory products (FhESP), and antibody responses (ELISA and Western blot) were studied in sheep during the first 3 months of an experimental primary or secondary infection. Expand
[Serum IgE levels in rats infected with Paragonimus westermani].
  • M. Shin, J. Ryu, D. Min
  • Biology, Medicine
  • Kisaengch'unghak chapchi. The Korean journal of parasitology
  • 1991
The present results suggested that P. westermani could elevate serum IgE and specific IgG antibodies in Wistar rats which were not a good definitive host. Expand
Immunological approaches for the control of fasciolosis.
Analysis of immune responses to Fasciola during infection in ruminants suggests that chronic infection correlates with a type 2 helper T cell response, implying that type 1 helpers T cell responses are down-regulated in fasciolosis. Expand
Immunization with cathepsin L proteinases CL1 and CL2 secreted by Fasciola hepatica elicit a preferential type 1 response based on IgG2a antibodies in rats.
Cathepsin L proteinases (CL1 and CL2), the major components of Fasciola hepatica excretion/secretion products (E/S) are considered potential antigens of a vaccine against fascioliasis. The humoralExpand
Cellular reactions in the small intestine of rats after infection withFasciola hepatica
The pattern of these defence reactions in the small intestine suggests some similarities with the mechanisms of antibody-dependent cell-mediated cytotoxicity that have been shown to take place during Schistosoma mansoni reinfection. Expand
Local immune response to experimental Fasciola hepatica infection in sheep.
The migratory tunnels produced by juvenile flukes appeared as local areas of necrosis surrounded by infiltrating inflammatory cells, particularly numerous macrophages, eosinophils and OvCD4+ lymphocytes n addition, B lymphocyte proliferation was observed in hepatic lymph nodes and in liver portal tracts. Expand
Worm kinetics and serum IgE in hooded lister rats infected with the acanthocephalan Moniliformis moniliformis and the nematode Nippostrongylus brasiliensis.
Anthelminthic removal of M. moniliformis revealed that the presence of residual worms was necessary to maintain worm-specific IgE production, and a peak response was observed about 1 month after the sera turned positive. Expand
IgE responses in human gnathostomiasis.
There was almost a 10-fold rise in the total IgE in the serum of patients with proven gnathostomiasis and in those with intermittent cutaneous migratory swellings, indicating that G. spinigerum infection potentiates IgE production similarly to many other nematode parasites. Expand


Elevation of total serum IgE in rats following helminth parasite infection
Infections with parasitic worms lead to the production of high levels of reaginic or IgE antibodies against parasite antigens, and greatly elevated levels of total IgE occur in most individuals infected with any one of a variety of helminths. Expand
Serum IgE levels in rats infected with Dipetalonema viteae L3 larvae.
Serum IgE levels were measured by radioimmunoassay in rats infected with various doses of L3 infective stage larvae of Dipetalonema viteae and a high stimulation was found with minute doses as well as with large doses of parasite. Expand
IgE in experiemental schistosomiasis. I. Serum IgE levels after infection by Schistosoma mansoni in various strains of rats.
Serum IgE levels were measured by radioimmunoassay in four strains of rats, before and after infection by Schistosoma mansoni. Differences were observed in basal IgE levels, depending on the strainExpand
IGE in Paragonimus ohirai-infected rats: relationship between titer, migration route, and parasite age.
Migration of the parasite in the peritoneal cavity and the liver was an important event in the production of IgE, because intrapleurally inoculated metacercariae normally develop into mature worms without migrating into the abdominal cavity. Expand
Homocytotropic antibody responses during murine schistosomiasis. A follow-up study of both total immunoglobulins and Schistosoma mansoni specific antibodies.
Mice infected with Schistosoma mansoni develop a high increase of homocytotropic antibodies, thought to be involved in protection, which are measured by passive cutaneous anaphylaxis parallel to variations of total IgE and IgG1. Expand
IgE in experimental schistosomiasis. II. Quantitative determination of specific IgE antibodies against S. mansoni: a follow-up study of two strains of infected rats. Correlation with protective immunity.
There was a close parallelism between specific IgE antibodies levels and the course of immunity in Fischer rats, which supports the view that IgE could play a pre-eminent role in protective immunity in rat schistosomiasis. Expand
Potentiation of rat reaginic (IgE) antibody by helminth infection. Simultaneous potentiation of separate reagins.
Further evidence has been produced that rat reaginic antibody responses which have been programmed by the injection of antigen with Bordetella pertussis can be greatly potentiated by a subsequentExpand
Time course studies on rat IgE production in N. Brasiliensis infection.
It is proposed that the total IgEresponse and the potentiated IgE response which forms a small component of it results from the release of a non-specific IgE-stimulating factor produced by N. brasiliensis-specific T cells. Expand
Transplantable immunoglobulin-secreting tumours in rats. IV. Sixty-three IgE-secreting immunocytoma tumours.
The inbred LOU/Wsl rat strain presents a high incidence of spontaneous ileocoecal immunocytoma which secrete monoclonal immunoglobulins. These tumours are transplantable in histocompatible animalsExpand
A Radioimmunoassay for Evaluation of the IgE and IgG Antibody Responses in the Rat
The results indicate that there is a relationship between the basic IgElevel and the immune response, i.e. a rat strain with a low constitutive IgE level demonstrates a weak response whereas a high level strain reacts strongly. Expand