IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

@article{Pne1988IgEPB,
  title={IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.},
  author={J{\'e}r{\^o}me P{\`e}ne and Françoise Rousset and Francine Bri{\`e}re and I Chr{\'e}tien and Jean Yves Bonnefoy and Hergen Spits and Takashi Yokota and Naoko Arai and Ken-ichi Arai and Jacques Banchereau},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 18},
  pages={6880-4}
}
The effect of human recombinant interleukin 4 (IL-4) on antibody production by normal peripheral blood mononuclear cells enriched for B cells was investigated. IL-4 preferentially induced IgE synthesis in vitro. In addition, a low induction of IgG production was observed, whereas IL-4 had no effect on IgA and IgM synthesis. The IL-4-induced IgE production by B cells required T cells and monocytes but was specifically inhibited by an anti-IL-4 antiserum indicating that, although IL-4 acts… CONTINUE READING

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