IgE production, antigen-induced airway inflammation and airway hyperreactivity in the brown Norway rat: the effects of ricin.

@article{Underwood1995IgEPA,
  title={IgE production, antigen-induced airway inflammation and airway hyperreactivity in the brown Norway rat: the effects of ricin.},
  author={Stephen L. Underwood and D{\'a}vid Mikl{\'o}s Kem{\'e}ny and Tae Hee Lee and David Antony Raeburn and Jennifer Anne. Karlsson},
  journal={Immunology},
  year={1995},
  volume={85 2},
  pages={
          256-61
        }
}
Ricin has been shown to enhance IgE production in the rat, probably through inhibition of suppressor T lymphocytes. We have studied further the effects of ricin on IgE titre and have determined its effects on antigen-induced airway inflammation and hyperreactivity in the Brown Norway rat. Immunization with ovalbumin (1-100 micrograms, intraperitoneally) produced dose-related increases in serum antigen-specific IgE titre. Ricin augmented the total IgE titre and caused about a 10-fold increase in… CONTINUE READING