IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis.

@article{Gurish2004IgEEP,
  title={IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis.},
  author={Michael F. Gurish and P J Bryce and Hong Tao and Alison B. Kisselgof and Elizabeth M. Thornton and Hugh R. P. Miller and Daniel Friend and Hans C. Oettgen},
  journal={Journal of immunology},
  year={2004},
  volume={172 2},
  pages={1139-45}
}
Trichinella spiralis infection elicits a vigorous IgE response and pronounced intestinal and splenic mastocytosis in mice. Since IgE both activates mast cells (MC) and promotes their survival in culture, we examined its role in MC responses and parasite elimination in T. spiralis-infected mice. During primary infection, wild-type but not IgE-deficient (IgE(-/-)) BALB/c mice mounted a strong IgE response peaking 14 days into infection. The splenic mastocytosis observed in BALB/c mice following… CONTINUE READING

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