IgE-dependent mast cell activation potentiates airway responses in murine asthma models.

@article{Mayr2002IgEdependentMC,
  title={IgE-dependent mast cell activation potentiates airway responses in murine asthma models.},
  author={Susanne I Mayr and Riaz I. Zuberi and Min Zhang and Jean de Sousa-Hitzler and Karen Ngo and Yasuko Kuwabara and Lan Yu and Wai-Ping Fung-Leung and Fu-tong Liu},
  journal={Journal of immunology},
  year={2002},
  volume={169 4},
  pages={2061-8}
}
We have studied murine models of asthma using FcepsilonRIalpha-chain-deficient (FcepsilonRIalpha(-/-)) mice to investigate the role of IgE-dependent mast cell activation in these models. When mice were either 1) immunized once with OVA in alum i.p. and then challenged with OVA intranasally, or 2) repeatedly immunized with OVA in the absence of adjuvant and subsequently challenged with nebulized OVA, FcepsilonRalpha(-/-) mice had significantly fewer eosinophils and lower IL-4 levels in their… CONTINUE READING

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