• Biology, Medicine
  • Published in
    Cellular and molecular…
    1994

IgE-dependent activation of Fc epsilon RII/CD23+ normal human keratinocytes: the role of cAMP and nitric oxide.

@article{Bcherel1994IgEdependentAO,
  title={IgE-dependent activation of Fc epsilon RII/CD23+ normal human keratinocytes: the role of cAMP and nitric oxide.},
  author={Pierre Andr{\'e} B{\'e}cherel and Mohammad Djavad Mossalayi and Laetitia Le Goff and Fateh Ouaaz and Bernard Dugas and J. J. Guillosson and Patrice Debr{\'e} and Michel Arock},
  journal={Cellular and molecular biology},
  year={1994},
  volume={40 3},
  pages={
          283-90
        }
}
Epidermal keratinocytes (EK) are exposed to multiple inflammatory stimuli and paracrine factors secreted by various dermal cells (lymphocytes, mast-cells, macrophages, fibroblasts) during wounding, cutaneous allergy and infections. We have previously demonstrated that following stimulation with interleukin-4 (IL-4) or interferon-gamma, human EK express the low affinity receptor for IgE (Fc epsilon RII/CD23) on their surface. In the present study, we showed that the ligation of CD23 by IgE/anti… CONTINUE READING