IgE binds asymmetrically to its B cell receptor CD23

  title={IgE binds asymmetrically to its B cell receptor CD23},
  author={Balvinder Dhaliwal and Marie O. Y. Pang and Anthony H Keeble and Louisa K. James and Hannah J Gould and James M McDonnell and Brian J. Sutton and Andrew J Beavil},
  booktitle={Scientific reports},
The antibody IgE plays a central role in allergic disease mechanisms. Its effector functions are controlled through interactions between the Fc region and two principal cell surface receptors FcεRI and CD23. The interaction with FcεRI is primarily responsible for allergic sensitization and the inflammatory response, while IgE binding to CD23 is involved in the regulation of IgE synthesis and allergen transcytosis. Here we present the crystal structure of a CD23/IgE-Fc complex and conduct… CONTINUE READING