IgE basement membrane zone antibodies induce eosinophil infiltration and histological blisters in engrafted human skin on SCID mice.

@article{Zone2007IgEBM,
  title={IgE basement membrane zone antibodies induce eosinophil infiltration and histological blisters in engrafted human skin on SCID mice.},
  author={John J. Zone and Ted B. Taylor and Christopher M. Hull and Linda A. Schmidt and Laurence J. Meyer},
  journal={The Journal of investigative dermatology},
  year={2007},
  volume={127 5},
  pages={
          1167-74
        }
}
Bullous pemphigoid (BP) is characterized by the deposition of IgG in the basement membrane zone, infiltration of eosinophils, and blister formation. The purpose of this study was to evaluate a potential role of IgE basement membrane antibodies in the histological findings of BP. LABD97 is a component of the shed ectodomain of bullous pemphigoid antigen 2. We have developed an IgE hybridoma to LABD97 antigen. This hybridoma was injected subcutaneously in SCID mice with engrafted human skin. A… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 52 CITATIONS, ESTIMATED 37% COVERAGE

IgE-mediated mechanisms in bullous pemphigoid and other autoimmune bullous diseases.

VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Bullous Diseases.

FILTER CITATIONS BY YEAR

2007
2019

CITATION STATISTICS

  • 1 Highly Influenced Citations