IgE alone promotes human lung mast cell survival through the autocrine production of IL-6

@article{Cruse2007IgEAP,
  title={IgE alone promotes human lung mast cell survival through the autocrine production of IL-6},
  author={Glenn Cruse and Sarah L Cockerill and Peter Bradding},
  journal={BMC Immunology},
  year={2007},
  volume={9},
  pages={2 - 2}
}
Mast cells play a key role in asthma and recent evidence indicates that their ongoing activation in this disease is mediated, in part, via IgE in the absence of antigen. In this study we have examined whether IgE alone enhances human lung mast cell (HLMC) survival. Purified HLMC were cultured for 4 weeks and survival assays then performed over 10 days following cytokine withdrawal in the presence or absence of human myeloma IgE. Quantitative real time RT-PCR was carried out to examine IL-6 mRNA… CONTINUE READING

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