IgE Inhibits Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Expression of Interferon-α by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus.

Abstract

OBJECTIVE Plasmacytoid dendritic cells (PDCs) play a central role in pathogenesis of systemic lupus erythematosus (SLE) through their unique ability to produce large amounts of type I interferon (IFN) upon Toll-like receptor 7 (TLR-7) and TLR-9 triggering. PDCs express specific surface regulatory receptors involved in negative regulation of IFNα secretion… (More)
DOI: 10.1002/art.39679

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Cite this paper

@article{Khoryati2016IgEIT, title={IgE Inhibits Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Expression of Interferon-α by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus.}, author={Liliane Khoryati and Jean-François Augusto and Emilie Shipley and C{\'e}cile Contin-Bordes and Isabelle Douchet and St{\'e}phane Mitrovic and M E Truchetet and Estibaliz Lazaro and Pierre Duffau and Lionel Couzi and Cl{\'e}ment Jacquemin and Thomas Barnetche and Pierre Vacher and Thierry Schaeverbeke and Patrick Blanco and Christophe Richez}, journal={Arthritis & rheumatology}, year={2016}, volume={68 9}, pages={2221-31} }