IgE, Reed-Sternberg cells, and eosinophilia in Hodgkin's disease.

  title={IgE, Reed-Sternberg cells, and eosinophilia in Hodgkin's disease.},
  author={Michael K. Samoszuk and E. Ramzi},
  journal={Leukemia & lymphoma},
  volume={9 4-5},
Tissues containing Hodgkin's disease tumors of the nodular sclerosis and mixed cellularity subtypes are frequently infiltrated by numerous degranulating eosinophils that release granule proteins such as eosinophil peroxidase and major basic protein. Until recently, the causes of the eosinophil infiltration and degranulation in Hodgkin's disease tumors were unknown. Analysis of Hodgkin's disease tissues by a sensitive and specific immunoperoxidase technique has now demonstrated the extensive… CONTINUE READING


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