IgD/λ plasmocytoma with immunoglobulin κ light-chain genes in the germ-line configuration

Human immunoglobulin (Ig) genes are rearranged in an ordered sequence of events during B-cell differentiation: starting at the IgH locus, a productive VHDJH rearrangement leads to the expression of μ chains. Light-chain gene rearrangements have been found in pre-B cells which express μ chains. In these cells rearrangements of Ig κ light-chain genes precede… CONTINUE READING