IgA nephropathy.

@article{Wyatt2013IgAN,
  title={IgA nephropathy.},
  author={Robert J. Wyatt and Bruce A Julian},
  journal={The New England journal of medicine},
  year={2013},
  volume={368 25},
  pages={
          2402-14
        }
}
From the Children’s Foundation Research Institute at Le Bonheur Children’s Hospital and the Department of Pediatrics, University of Tennessee Health Science Center, Memphis (R.J.W.); and the Department of Medicine, University of Alabama at Birmingham, Birmingham (B.A.J.). Address reprint requests to Dr. Wyatt at Rm. 520, Children’s Foundation Research Institute, 50 North Dunlap, Memphis, TN 38103, or at rwyatt@uthsc .edu. 
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311 Citations
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Results Citations
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CiRCULATiNG igA-CONTAiNiNG iMMUNe COMPLeXeS iN igA NePHROPATHY AND HeNOCH – SCHÖNLeiN PURPURA NePHRiTiS
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This review paper discusses the most uptodate aspects of the pathogenesis, pathological classification and clinical implications of IgAN.
Why Target the Gut to Treat IgA Nephropathy?
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This review focuses on the clinical manifestations and management of the common forms of acute GN encountered in children.
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TLDR
A difference in terms of pathological, clinical and laboratory presentations of IgAN between males and females is found and men generally had worse kidney function at presentation and advanced Oxford classification in their kidney biopsies compared to women.
IgA nephropathy: A brief review.
TLDR
The varied histologic features that are important in the diagnosis of IgA nephropathy are explained and the calculation of the MEST-C score that was first introduced by the 2009 Oxford Classification working group is explained.
Changes in the clinical presentation of immunoglobulin A nephropathy: data from the Spanish Registry of Glomerulonephritis
  • E. Gutiérrez, M. Praga, +4 authors J. López-Gómez
  • Medicine
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2018
TLDR
Although the prevalence of IgAN in Spain has remained stable over the years, patients are significantly older and present with significantly worse renal function in the last years.
IgA nephropathy in adult-onset Still’s disease after tocilizumab treatment: a case report
  • Ji-Hyoun Kang
  • Medicine, Biology
    International Urology and Nephrology
  • 2021
TLDR
Although the patient was treated with high dosages of prednisolone, methotrexate, and calcineurin inhibitor for 6 months after diagnosis, his symptoms, including fever, skin rash, and arthritis, were intermittent and uncontrolled.
Correlation of Oxford MEST-C Scores With Clinical Variables for IgA Nephropathy in South India
The genetics and immunobiology of IgA nephropathy.
TLDR
New insights are summarized into the role of the O-glycosylation pathway, anti-glycan immune response, mucosal immunity, antigen processing and presentation, and the alternative complement pathway in the pathogenesis of IgAN.
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References

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IgA nephropathy in the triethnic population of New Mexico.
TLDR
This is the first report of an incidence figure of IgAN for an entire state in the US, and American Indian and Hispanic patients had a stronger representation in the authors' cohort than Non-Hispanic Whites, when compared to the general New Mexico population.
A tricontinental view of IgA nephropathy.
  • C. Geddes, V. Rauta, +5 authors D. Cattran
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    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
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TLDR
The findings are consistent with the hypothesis that geographical variability in long-term outcome of IgAN is explained by lead-time bias and inclusion of milder cases in centres with apparent good outcome, but do not exclude the possibility that some of the variability is due to other factors such as genetics, diet or treatment.
IgA nephropathy: progress before and since Berger.
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    American journal of kidney diseases : the official journal of the National Kidney Foundation
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TLDR
The significance of Berger's first report is reflected, the days before Berger, when IgAN could not have been identified, and classification of glomerulonephritis was even more contentious and confusing than it is today.
Incidence of pediatric IgA nephropathy
TLDR
Twenty cases of pediatric IgA nephropathy were detected over the past 17 years in Yonago City, Japan, and the incidence rate was 4.5 cases/year per 100,000 children under 15 years, higher than that of idiopathic nephrotic syndrome.
Immune complex formation in IgA nephropathy: a case of the 'right' antibodies in the 'wrong' place at the 'wrong' time?
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  • Biology
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
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TLDR
Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity by researchers at the National Institutes of Health.
The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults.
TLDR
The cross-sectional correlation between pathology and proteinuria was similar in adults and children and the predictive value of each specific lesion on the rate of decline of renal function or renal survival in IgA nephropathy was not different between children and adults.
Long-term outcome 19 years after childhood IgA nephritis: a retrospective cohort study
TLDR
Long-term follow-up during adulthood is needed even after mild childhood IgA nephritis, especially in women during and after pregnancy, and in patients with persistent nephropathy or ESRD.
Is IgA nephropathy the commonest primary glomerulopathy among young adults in the USA?
TLDR
It is suggested that IgA nephropathy (IgAN) may be the most common primary glomerulopathy and the mostCommon cause of ESRD in young adult Caucasians in the USA.
Pre‐transplant course and risk of kidney transplant failure in IgA nephropathy patients
TLDR
The pre‐transplant course and risk of kidney transplant failure in IgA nephropathy patients is higher in patients with a history of kidney failure than in those with normal kidney function.
Regression of IgA nephropathy: a repeat biopsy study.
TLDR
It is indicated that mesangial proliferation and interstitial changes in IgA nephropathy are reversible to a considerable extent and a histological cure may be obtainable in a considerable proportion of patients, especially if treatment is initiated at a relatively early stage.
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