IgA nephropathy with early kidney disease is associated with increased arterial stiffness and renin-angiotensin system activity.

@article{AbdiAli2015IgANW,
  title={IgA nephropathy with early kidney disease is associated with increased arterial stiffness and renin-angiotensin system activity.},
  author={Ahmed Abdi-Ali and Michelle Catherine Mann and Brenda R. Hemmelgarn and Jennifer Marie Macrae and Tanvir C Turin and Hallgrimur Benediktsson and Darlene Y. Sola and Sofia B. Ahmed},
  journal={Journal of the renin-angiotensin-aldosterone system : JRAAS},
  year={2015},
  volume={16 3},
  pages={521-8}
}
BACKGROUND IgA nephropathy is associated with increased cardiovascular risk, though whether this is due to loss of kidney function or proteinuria is unclear. METHODS For this study 10 normotensive IgA nephropathy subjects with early kidney disease (41±5 yrs, glomerular filtration rate (GFR) 87±9 ml/min, proteinuria 720±300 mg/d) and 10 gender- and blood pressure-matched healthy controls (36±1 yrs, estimated GFR 102±5 ml/min, proteinuria 70±6 mg/d) were studied in high-salt balance. Blood… CONTINUE READING