IgA nephropathy: lessons from an animal model, the ddY mouse.

@article{Tomino2008IgANL,
  title={IgA nephropathy: lessons from an animal model, the ddY mouse.},
  author={Yasuhiko Tomino},
  journal={Journal of nephrology},
  year={2008},
  volume={21 4},
  pages={463-7}
}
IgA nephropathy is the most common primary chronic glomerulonephritis, and was first described by J. Berger (Transplant Proc. 1969;1:939-944). Histopathologically, IgA nephropathy is characterized by expansion of glomerular mesangial matrix, with mesangial cell proliferation. Glomeruli typically contain generalized-diffuse granular mesangial deposits of IgA, IgG and C3. Since pathogenesis of IgA nephropathy is still obscure, it is important to try to determine the initiation and progression of… CONTINUE READING