IgA-mediated human autoimmune hemolytic anemia as a result of hemagglutination in the spleen, but independent of complement activation and FcαRI.

@article{Chadebech2010IgAmediatedHA,
  title={IgA-mediated human autoimmune hemolytic anemia as a result of hemagglutination in the spleen, but independent of complement activation and FcαRI.},
  author={Philippe Chadebech and Marc Michel and D. Vanhoenackel Janvier and Kazunori Yamada and Christiane Copie-Bergman and Gwellaouen Bodivit and Armand Bensussan and Jean-Jacques Fourni{\'e} and Bertrand Godeau and Philippe Bierling and Shozo Izui and France Noizat-Pirenne},
  journal={Blood},
  year={2010},
  volume={116 20},
  pages={
          4141-7
        }
}
Autoimmune hemolytic anemia (AIHA) due to warm-acting IgA autoantibodies is rare. We explored the pathogenic mechanisms underlying destruction of red blood cells (RBCs) in a patient with severe AIHA mediated exclusively by polymeric immunoglobulin A (pIgA) anti-Band 3 autoantibodies. The follow-up period was 17 months. RBCs were not destroyed by complement activation as no deposition of complement was observed on the patient's RBCs. pIgA eluted from the patient's RBCs did not induce RBC… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 28 REFERENCES

Similar Papers

Loading similar papers…