Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction.

@article{Li2009IglikeT4,
  title={Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction.},
  author={Demin Li and Lili Wang and Li Yu and Eric C. Freundt and Boquan Jin and Gavin Robert Screaton and Xiao-ning Xu},
  journal={Journal of immunology},
  year={2009},
  volume={182 2},
  pages={1033-40}
}
NKT cells recognize lipid Ags presented by CD1d molecules and play an important role in the regulation of innate and adaptive immune responses. In this study, we report the identification of a membrane-associated protein, Ig-like transcript 4 (ILT4), as a novel human CD1d receptor that inhibits CD1d-mediated immune responses. We found that native CD1d… CONTINUE READING