Ig-like domains: evolution from simple interaction molecules to sophisticated antigen recognition.

  • Alexander Barclay
  • Published 1999 in
    Proceedings of the National Academy of Sciences…


T vertebrate immune system is remarkable because it can recognize virtually any foreign material or antigen and yet not react against itself except in those rare cases when autoimmunity results. Over the last 20 years the mechanisms by which antigens are recognized by the B cell antigen receptor (Ig) and the T cell antigen receptor (TcR) have been well… (More)


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