Ig light chain receptor editing in anergic B cells.

  title={Ig light chain receptor editing in anergic B cells.},
  author={Lina E. Tze and Elizabeth A. Baness and Keli L. Hippen and Timothy W. Behrens},
  journal={Journal of immunology},
  volume={165 12},
Receptor editing in the bone marrow (BM) serves to modify the Ag receptor specificity of immature self-reactive B cells, while anergy functionally silences self-reactive clones. Here, we demonstrate that anergic B cells in hen egg lysozyme Ig (HEL-Ig)/soluble HEL double transgenic mice show evidence of having undergone receptor editing in vivo, as demonstrated by the presence of elevated levels of endogenous kappa light chain rearrangements in the BM and spleen. In an in vitro IL-7-driven BM… CONTINUE READING


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