Ig heavy chain gene rearrangements in T-cell acute lymphoblastic leukemia exhibit predominant DH6-19 and DH7-27 gene usage, can result in complete V-D-J rearrangements, and are rare in T-cell receptor alpha beta lineage.

@article{Szczepanski1999IgHC,
  title={Ig heavy chain gene rearrangements in T-cell acute lymphoblastic leukemia exhibit predominant DH6-19 and DH7-27 gene usage, can result in complete V-D-J rearrangements, and are rare in T-cell receptor alpha beta lineage.},
  author={Tomasz Szczepanski and M J Pongers-Willemse and Anton W. Langerak and W A Harts and Annemarie J. M. Wijkhuijs and Elisabeth R van Wering and Jacques JM van Dongen},
  journal={Blood},
  year={1999},
  volume={93 12},
  pages={4079-85}
}
Rearranged IGH genes were detected by Southern blotting in 22% of 118 cases of T-cell acute lymphoblastic leukemia (ALL) and involved monoallelic and biallelic rearrangements in 69% (18/26) and 31% (8/26) of these cases, respectively. IGH gene rearrangements were found in 19% (13/69) of CD3(-) T-ALL and in 50% of TCRgammadelta+ T-ALL (12/24), whereas only a single TCRalpha beta+ T-ALL (1/25) displayed a monoallelic IGH gene rearrangement. The association with the T-cell receptor (TCR) phenotype… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

Similar Papers

Loading similar papers…