Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance.

@article{Ma2010IgGM,
  title={Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance.},
  author={Liang Ma and Claudio Mauro and Georgina H. Cornish and Jian-Guo Chai and David Coe and Hongmei Fu and Daniel Timothy Patton and Klaus Okkenhaug and Guido Franzoso and Julian P. Dyson and Sussan Nourshargh and Federica M. Marelli-Berg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 45},
  pages={
          19461-6
        }
}
CD31 is an Ig-like molecule expressed by leukocytes and endothelial cells with an established role in the regulation of leukocyte trafficking. Despite genetic deletion of CD31 being associated with exacerbation of T cell-mediated autoimmunity, the contribution of this molecule to T-cell responses is largely unknown. Here we report that tumor and allograft rejection are significantly enhanced in CD31-deficient mice, which are also resistant to tolerance induction. We propose that these effects… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 42 CITATIONS

An immunologist's guide to CD31 function in T-cells.

VIEW 17 EXCERPTS
CITES BACKGROUND

CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo.

VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND

CD31 signals confer immune privilege to the vascular endothelium.

VIEW 3 EXCERPTS
CITES BACKGROUND & RESULTS

Altered CD31 expression and activity in helper T cells of acute coronary syndrome patients

VIEW 5 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Regulation of B cell responses during Salmonella Typhimurium infection

VIEW 5 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Overlapping, Additive and Counterregulatory Effects of Type II and I Interferons on Myeloid Dendritic Cell Functions

VIEW 4 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

Acceleration of the onset of collagen-induced arthritis by a deficiency of platelet endothelial cell adhesion molecule 1

  • Y Tada
  • Arthritis Rheum
  • 2003