Ig-binding surface proteins of Streptococcus pyogenes also bind human C4b-binding protein (C4BP), a regulatory component of the complement system.

@article{Thern1995IgbindingSP,
  title={Ig-binding surface proteins of Streptococcus pyogenes also bind human C4b-binding protein (C4BP), a regulatory component of the complement system.},
  author={Anette M Thern and Leisa M. Stenberg and Bj{\"o}rn Dahlb{\"a}ck and Gunnar Lindahl},
  journal={Journal of immunology},
  year={1995},
  volume={154 1},
  pages={
          375-86
        }
}
Streptococcus pyogenes, an important human pathogen, expresses several proteins that interact with the immune system of the host. Among the proteins isolated from different bacterial strains are antiphagocytic M proteins, Ig Fc-binding proteins and exotoxins that act as superantigens. Here we report a novel interaction between S. pyogenes and the human immune system, the ability of most S. pyogenes strains to bind human C4BP (C4b-binding protein), a 570-kDa serum protein that inhibits the… CONTINUE READING

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