Ifosfamide or trofosfamide in patients with intraocular lymphoma

  title={Ifosfamide or trofosfamide in patients with intraocular lymphoma},
  author={Kristoph Jahnke and Eckhard Thiel and Nikolaos E. Bechrakis and Gregor D. Willerding and Dale Kraemer and Lars Fischer and Agnieszka Korfel},
  journal={Journal of Neuro-Oncology},
We evaluated response, progression-free survival (PFS), overall survival (OS), relapse patterns and long-term toxicity of intraocular lymphoma (IOL) patients treated with ifosfamide (IFO) or trofosfamide (TRO). In a prospective single center study, IFO or TRO were given to 10 patients with IOL. The median patient age was 73 (range 46–83) years. Six patients were pretreated with up to four treatment regimens for ocular or cerebral lymphoma, and four were therapy-naive. All patients responded… 

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  • K. JahnkeT. Wagner A. Korfel
  • Medicine
    Annals of oncology : official journal of the European Society for Medical Oncology
  • 2005
IOL patients evidence aqueous penetration of 4-OH metabolites after intravenous administration of IFO, and IFO and TRO are active in IOL.

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The prognosis of PIOL is similar to that of PCNSL without ocular involvement, and the high response rate to monotherapy with IFO and TRO is promising, which possibly prolongs PFS as compared with local management of (P)IOL.

Treatment of primary CNS lymphoma with methotrexate and deferred radiotherapy: a report of NABTT 96-07.

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  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2003
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  • A. FerreriJ. Blay F. Cavalli
  • Medicine
    Annals of oncology : official journal of the European Society for Medical Oncology
  • 2002
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  • S. GrimmJ. Pulido L. Abrey
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2006
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