Ifosfamide impairs the allostimulatory capacity of human dendritic cells by intracellular glutathione depletion.

@article{Kuppner2003IfosfamideIT,
  title={Ifosfamide impairs the allostimulatory capacity of human dendritic cells by intracellular glutathione depletion.},
  author={Maria C. Kuppner and Anabel Scharner and Valeria Milani and Christoph von Hesler and Katharina E Tschop and Oksana Heinz and Rolf Dieter Issels},
  journal={Blood},
  year={2003},
  volume={102 10},
  pages={3668-74}
}
Ifosfamide, a clinically potent chemotherapeutic agent, causes the depletion of intracellular glutathione (GSH) levels in various cell types. GSH is the major intracellular reductant against oxidative stress. 4-Hydroxyifosfamide (4-OH-IF), the activated form of ifosfamide, depletes GSH levels in T cells and natural killer (NK) cells; this is accompanied by a decrease in T-cell and NK-cell function. Here we demonstrate for the first time that human monocyte-derived dendritic cells (DCs) express… CONTINUE READING
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