Ifenprodil inhibition of the 5-hydroxytryptamine3 receptor.

  title={Ifenprodil inhibition of the 5-hydroxytryptamine3 receptor.},
  author={Brian A McCool and David M. Lovinger},
  volume={34 6},
The anti-hypertensive drug ifenprodil is known to interact potently with the alpha 1-adrenergic receptor as well as a number of other second messenger-linked receptors. In addition to these properties, ifenprodil has been shown to prevent glutamate-mediated excitotoxicity via non-competitive antagonism of NMDA receptors [Legendre and Westbrook (1991) Molec. Pharmac. 40: 289-298; Shalaby et al. (1992) J. Pharmac. Exp. Ther. 260: 925-932]. With these things in mind, we have begun to examine the… CONTINUE READING


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