Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism.

  title={Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism.},
  author={Pascal Legendre and Gary L Westbrook},
  journal={Molecular pharmacology},
  volume={40 2},
The inhibition of N-methyl-D-aspartate (NMDA) receptor channels by the vasodilatory and anti-ischemic agent ifenprodil was examined on cultured rat hippocampal neurons. Whole-cell and single-channel patch recordings were used. Ifenprodil inhibition of NMDA currents could be separated into two components, with IC50 values of 0.75 and 161 microM. The high and low affinity components were both voltage independent but could be separated by their kinetics and dependence on extracellular calcium and… CONTINUE READING

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