If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans.

  title={If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans.},
  author={Gregory E. Miller and Edith Chen and Eric S. Zhou},
  journal={Psychological bulletin},
  volume={133 1},
The notion that chronic stress fosters disease by activating the hypothalamic-pituitary-adrenocortical (HPA) axis is featured prominently in many theories. The research linking chronic stress and HPA function is contradictory, however, with some studies reporting increased activation, and others reporting the opposite. This meta-analysis showed that much of the variability is attributable to stressor and person features. Timing is an especially critical element, as hormonal activity is elevated… 

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