Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death

@article{Andrabi2011IdunaPT,
  title={Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death},
  author={Shaida A Andrabi and Ho Chul Kang and Jean-François Haince and Yun-il Lee and Jian Zhang and Zhikai Chi and A Brian West and Raymond C Koehler and Guy G. Poirier and Ted M Dawson and Valina L Dawson},
  journal={Nature Medicine},
  year={2011},
  volume={17},
  pages={692-699}
}
Glutamate acting on N-methyl-D-aspartate (NMDA) receptors induces neuronal injury following stroke, through activation of poly(ADP-ribose) polymerase-1 (PARP-1) and generation of the death molecule poly(ADP-ribose) (PAR) polymer. Here we identify Iduna, a previously undescribed NMDA receptor–induced survival protein that is neuroprotective against glutamate NMDA receptor–mediated excitotoxicity both in vitro and in vivo and against stroke through interfering with PAR polymer–induced cell death… CONTINUE READING