Corpus ID: 1057649

Idoxifene antagonizes estradiol-dependent MCF-7 breast cancer xenograft growth through sustained induction of apoptosis.

@article{Johnston1999IdoxifeneAE,
  title={Idoxifene antagonizes estradiol-dependent MCF-7 breast cancer xenograft growth through sustained induction of apoptosis.},
  author={S. Johnston and I. Boeddinghaus and S. Riddler and B. P. Haynes and I. Hardcastle and M. Rowlands and R. Grimshaw and M. Jarman and M. Dowsett},
  journal={Cancer research},
  year={1999},
  volume={59 15},
  pages={
          3646-51
        }
}
  • S. Johnston, I. Boeddinghaus, +6 authors M. Dowsett
  • Published 1999
  • Medicine
  • Cancer research
  • Idoxifene is a novel selective estrogen (E2) receptor (ER) modulator that is currently in clinical development for the treatment of breast cancer. Compared to tamoxifen, idoxifene is metabolically more stable, with a higher relative binding affinity for the ER and reduced agonist activity on breast and uterine cells. Idoxifene also inhibits calmodulin, a calcium-binding protein that is involved in cell signal transduction pathways. In this study, the abilities of idoxifene and tamoxifen to… CONTINUE READING
    Mechanisms of tamoxifen-induced apoptosis
    • 360

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