Idoxifene antagonizes estradiol-dependent MCF-7 breast cancer xenograft growth through sustained induction of apoptosis.

@article{Johnston1999IdoxifeneAE,
  title={Idoxifene antagonizes estradiol-dependent MCF-7 breast cancer xenograft growth through sustained induction of apoptosis.},
  author={Stephen R. D. Johnston and Irene Boeddinghaus and Sharon A. Riddler and Ben P. Haynes and Ian R. Hardcastle and Martin Rowlands and Rachel Grimshaw and Michael Jarman and Mitch Dowsett},
  journal={Cancer research},
  year={1999},
  volume={59 15},
  pages={3646-51}
}
Idoxifene is a novel selective estrogen (E2) receptor (ER) modulator that is currently in clinical development for the treatment of breast cancer. Compared to tamoxifen, idoxifene is metabolically more stable, with a higher relative binding affinity for the ER and reduced agonist activity on breast and uterine cells. Idoxifene also inhibits calmodulin, a calcium-binding protein that is involved in cell signal transduction pathways. In this study, the abilities of idoxifene and tamoxifen to… CONTINUE READING

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