Ido expression by dendritic cells: tolerance and tryptophan catabolism

@article{Mellor2004IdoEB,
  title={Ido expression by dendritic cells: tolerance and tryptophan catabolism},
  author={Andrew L Mellor and David H. Munn},
  journal={Nature Reviews Immunology},
  year={2004},
  volume={4},
  pages={762-774}
}
Key PointsThe peripheral immune system can promote either immunity or tolerance when presented with new antigens. Dendritic cells (DCs) have a crucial role in determining immune outcomes by acquiring antigens, collating environmental cues and then becoming cells that are either potent stimulators or suppressors of T-cell responses.Enzymatic activity of indoleamine 2,3-dioxygenase (IDO) correlates with reduced T-cell-mediated responses in several experimental (mouse) systems, including models of… CONTINUE READING

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