Idiotypic specificities of anti-Rh antibodies.

@article{Natvig1976IdiotypicSO,
  title={Idiotypic specificities of anti-Rh antibodies.},
  author={Jacob B. Natvig and Henry G. Kunkel and Richard E. Rosenfield and John F. Dalton and S Kochwa},
  journal={Journal of immunology},
  year={1976},
  volume={116 6},
  pages={1536-8}
}
Idiotypic antibodies were produced in rabbits to Rh antibodies isolated from the serum of an individual with high Rh antibody titer. These antisera after absorption with blood IgG failed to react with immunoglobulins lacking anti-Rh activity. They agglutinated cells coated with the immunizing antibody to high titers. Two other anti-Rh coats out of 22 tested also were agglutinated but to considerably reduced titers indicating a degree of anti-Rh cross specificity. Four other antisera made to red… CONTINUE READING