Idiotypic regulation of development of the B-cell repertoire.


The mouse B-cell repertoire develops from a restricted set to an extremely diverse set of specificities. Establishment of some of the B-cell clones that constitute the adult repertoire is facilitated and guided by idiotype-directed interactions among complementary sets of B cells early during ontogeny. Through in vivo experiments described here and reported… (More)


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@article{Elliott1992IdiotypicRO, title={Idiotypic regulation of development of the B-cell repertoire.}, author={Marc N. Elliott and Joseph F. Kearney}, journal={Annals of the New York Academy of Sciences}, year={1992}, volume={651}, pages={336-45} }