Idiotype and antigen-specific T cell responses in mice on immunization with antigen, antibody, and anti-idiotypic antibody.

@article{MitraKaushik2001IdiotypeAA,
  title={Idiotype and antigen-specific T cell responses in mice on immunization with antigen, antibody, and anti-idiotypic antibody.},
  author={Shibani Mitra-Kaushik and Melkote Subbarao Shaila and A. Karande and Rabindranath Nayak},
  journal={Cellular immunology},
  year={2001},
  volume={209 2},
  pages={109-19}
}
Idiotypic determinants of immunoglobulin molecules can evoke both CD4(+) and CD8(+) T responses and exist not only as the integral components of a bona fide antigen binding receptor but also as distinct molecular entities in the processed forms on the cell surface of B lymphocytes. The present work provides experimental evidence for the concept that regulation of memory B cell populations can be achieved through the presentation of idiotypic and anti-idiotypic determinants to helper and… CONTINUE READING