Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onset.

@article{Fontana2014IdiosyncraticDL,
  title={Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onset.},
  author={Robert J Fontana and Paul H. Hayashi and Jiezhun Gu and K Rajender Reddy and Huiman X. Barnhart and Paul B Watkins and Jos{\'e} Serrano and William M. Lee and Naga P Chalasani and Andrew Stolz and Timothy J. Davern and Jayant A Talwakar},
  journal={Gastroenterology},
  year={2014},
  volume={147 1},
  pages={
          96-108.e4
        }
}
BACKGROUND & AIMS Little is known about the incidence of drug-induced liver injury (DILI) and risk factors for adverse outcomes. We evaluated short-term outcomes of a large cohort of patients with DILI enrolled in an ongoing multicenter prospective study. METHODS Data were collected from 660 adults with definite, highly likely, or probable DILI. Regression methods were used to identify risk factors for early liver-related death or liver transplantation and chronic liver injury. RESULTS… CONTINUE READING

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