Idiosyncratic adverse reactions to antiepileptic drugs.

  title={Idiosyncratic adverse reactions to antiepileptic drugs.},
  author={G. Zaccara and Diego Franciotta and Emilio Perucca},
  volume={48 7},
Idiosyncratic drug reactions may be defined as adverse effects that cannot be explained by the known mechanisms of action of the offending agent, do not occur at any dose in most patients, and develop mostly unpredictably in susceptible individuals only. These reactions are generally thought to account for up to 10% of all adverse drug reactions, but their frequency may be higher depending on the definition adopted. Idiosyncratic reactions are a major source of concern because they encompass… CONTINUE READING
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