Idiopathisches multiples Pigmentsarkom der Haut

  title={Idiopathisches multiples Pigmentsarkom der Haut},
  journal={Archiv f{\"u}r Dermatologie und Syphilis},
  • Kaposi
  • Published 2005
  • Medicine
  • Archiv für Dermatologie und Syphilis
Humanized Mice as a Model to Study Human Viral Pathogenesis and Novel Antiviral Drugs
It is shown that these mice sustain long term engraftment and systemic expansion of human cells, including the major targets of Kaposi’s sarcoma Herpesvirus (KSHV) and Human immunodeficiency virus type 1 (HIV-1), in peripheral blood and different lymphoid organs. Expand
Utilising omics approaches to understand Kaposi's sarcoma-associated herpesvirus
Light is shed on previously unidentified mechanisms employed by KSHV to hijack the host cell, and may aid in the development of novel therapeutics against this important pathogen. Expand
Characterisation of the interactions between the KSHV ORF57 protein and the human TREX complex
A series of compounds are presented that are able to prevent both KSHV and HSV-1 lytic replication, and a hit compound identified was shown to disrupt formation of the vRNP, lytic protein expression and infectious virions, while allowing endogenous hTREX formation within a therapeutic window, where no cytotoxicity was observed. Expand
Identification of novel tumor predisposition families and underlying genetic defects
A registry based familial clustering of cancers in Finland based on STAT4 as a candidate susceptibility gene for Kaposi sarcoma and the results show that STAT4 activation is not affected by p.Thr446Ile mutation. Expand
KSHV: pathways to tumorigenesis and persistent infection.
This comprehensive chapter will discuss the diseases associated with KSHV infection, the biology of latent and lytic infection, and individual proteins and microRNAs that are known to contribute to host cell transformation and immune evasion. Expand
Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma
Whole-exome sequencing reveals a homozygous splice-site mutation in the gene encoding STIM1 in a child with classic Kaposi sarcoma.
Academic relationships between Hungarian professors and the Second Vienna Medical School
The impact of the ‘second’ Vienna Medical School, hallmarked by Karl Rokitansky, Joseph Skoda and Ferdinand Hebra, on the study and practice of medicine in Hungary is discussed. Expand
Epithelioid Kaposi Sarcoma: A New Histological Variant.
A 56-year-old Peruvian man who had been diagnosed with classical KS on the right foot 2 years before the present episode presented in the clinic with new lesions on the left foot with a diagnosis of epithelioid Kaposi sarcoma, which should be considered a new histological variant. Expand
HIV-Associated Cutaneous Kaposi's Sarcoma
A case of cutaneous KS in a 31-year-old male with an unknown positive HIV status, who could not tolerate the antiretroviral therapy and had unfortunate consequences is reported. Expand
Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling
It is shown that the HHV-8 envelope glycoprotein complex gH/gL binds with sub-nanomolar affinity to EphA2 via molecular mimicry of the receptor’s cellular ligands, ephrins, revealing a pivotal role for the conserved gH residue E52 and the amino-terminal peptide of gL. Expand