Idiopathic restrictive cardiomyopathy in children is caused by mutations in cardiac sarcomere protein genes.

@article{Kaski2008IdiopathicRC,
  title={Idiopathic restrictive cardiomyopathy in children is caused by mutations in cardiac sarcomere protein genes.},
  author={Juan Pablo Kaski and Petros Syrris and Michael Burch and M-T Tom{\'e}-Esteban and Matthew Fenton and Michael Christiansen and Paal Skytt Andersen and Neil J Sebire and Mark Ashworth and John Eric Deanfield and William J. McKenna and Perry M Elliott},
  journal={Heart},
  year={2008},
  volume={94 11},
  pages={1478-84}
}
BACKGROUND Restrictive cardiomyopathy (RCM) is rare in childhood, but has a grave prognosis. The cause of disease in most cases is unknown. OBJECTIVE To determine the prevalence of sarcomere protein gene mutations in children with idiopathic RCM. METHODS Twelve patients (9 female, mean age 5.1 years) with idiopathic RCM referred between 1991 and August 2006 underwent detailed clinical and genetic evaluation. Nine had received cardiac transplants at the time of the study. The entire coding… CONTINUE READING

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Four patients ( 33% ) had a family history of cardiomyopathy : RCM ( n = 2 ) ; dilated cardiomyopathy ( n = 1 ) and left ventricular non - compaction ( n = 1 ) .
Four patients ( 33% ) had a family history of cardiomyopathy : RCM ( n = 2 ) ; dilated cardiomyopathy ( n = 1 ) and left ventricular non - compaction ( n = 1 ) .
Four patients ( 33% ) had a family history of cardiomyopathy : RCM ( n = 2 ) ; dilated cardiomyopathy ( n = 1 ) and left ventricular non - compaction ( n = 1 ) .
Four patients ( 33% ) had a family history of cardiomyopathy : RCM ( n = 2 ) ; dilated cardiomyopathy ( n = 1 ) and left ventricular non - compaction ( n = 1 ) .
Four patients ( 33% ) had a family history of cardiomyopathy : RCM ( n = 2 ) ; dilated cardiomyopathy ( n = 1 ) and left ventricular non - compaction ( n = 1 ) .
Four patients ( 33% ) had a family history of cardiomyopathy : RCM ( n = 2 ) ; dilated cardiomyopathy ( n = 1 ) and left ventricular non - compaction ( n = 1 ) .
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