Idiopathic restrictive cardiomyopathy in children is caused by mutations in cardiac sarcomere protein genes

@article{Kaski2008IdiopathicRC,
  title={Idiopathic restrictive cardiomyopathy in children is caused by mutations in cardiac sarcomere protein genes},
  author={J. Kaski and P. Syrris and M. Burch and M. Tom{\'e}-Esteban and M. Fenton and M. Christiansen and P. Andersen and N. Sebire and M. Ashworth and J. Deanfield and W. McKenna and P. Elliott},
  journal={Heart},
  year={2008},
  volume={94},
  pages={1478 - 1484}
}
Background: Restrictive cardiomyopathy (RCM) is rare in childhood, but has a grave prognosis. The cause of disease in most cases is unknown. Objective: To determine the prevalence of sarcomere protein gene mutations in children with idiopathic RCM. Methods: Twelve patients (9 female, mean age 5.1 years) with idiopathic RCM referred between 1991 and August 2006 underwent detailed clinical and genetic evaluation. Nine had received cardiac transplants at the time of the study. The entire coding… Expand
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