Idiopathic pulmonary fibrosis--a sticky business.

Abstract

Pulmonary fibrosis comprises a spectrum of disease phenotypes, including familial and idiopathic forms. Current research suggests that pulmonary fibrosis is a “two-hit” disease: a genetic predisposition to abnormal alveolar epithelial-cell regulation of the cell cycle and apoptosis combined with environmental stressors, including exposure to known… (More)
DOI: 10.1056/NEJMe1014191

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