Idiopathic interstitial pneumonias: Primum movens: epithelial, endothelial or whatever.

@article{Calabrese2005IdiopathicIP,
  title={Idiopathic interstitial pneumonias: Primum movens: epithelial, endothelial or whatever.},
  author={Fiorella Calabrese and C. Giacometti and Federico Rea and Monica Loy and Marialuisa Valente},
  journal={Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG},
  year={2005},
  volume={22 Suppl 1},
  pages={S15-23}
}
The pathogenesis of idiopathic interstitial pneumonias (IIPs), particularly of idiopathic pulmonary fibrosis (IPF), is still unknown and the precise nature of the primum movens is strongly debated. Epithelial cells can be the first target of various environmental toxic agents. Both types of pneumocytes may be injured. Type I pneumocyte loss, however, is most conspicuous in fibroblastic foci, the principal sites where irreversible fibrogenesis starts. Epithelial regeneration is highly disturbed… CONTINUE READING