Idiopathic hyperphosphatasia with dermal pigmentation. A twenty-year follow-up.

  title={Idiopathic hyperphosphatasia with dermal pigmentation. A twenty-year follow-up.},
  author={J. R. D{\"o}hler and William Alexander Souter and Ian Beggs and G. D. Smith},
  journal={The Journal of bone and joint surgery. British volume},
  volume={68 2},
Hyperphosphatasia, or hereditary bone dysplasia with hyperphosphatasaemia, is a rare genetic disorder which is characterised by failure to transform woven into lamellar bone. Clinical, radiological and histological features establish the diagnosis, fractures, deformities, diffuse sclerosis on radiographs and high serum alkaline phosphatase being characteristic. We report the case of a 27-year-old man with follow-up at the same hospital for 20 years. Attempts at treatment with calcitonin and… 

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