Idiopathic Pulmonary Fibrosis and Mutation of TGF-beta Gene , Codon 10

Abstract

Background: Idiopathic pulmonary fibrosis (IPF) is associated with histological appearance of usual interstitial pneumonia. These fibrotic changes in lung interstitium are mostly attributed to cytokine production such as TGFβ which stimulate migration and differentiation of fibroblast to myofibroblasts. The polymorphism of TGFβ gene was found to be… (More)

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